Tribe Feed Forums 2024 Insight Parkinson’s and Mitohormesis | Dr Matthew Phillips Reply To: Parkinson’s and Mitohormesis | Dr Matthew Phillips

  • Matthew Phillips

    11/04/2024 at 2:58 pm

    Hi Suzy, surprisingly this is debatable. For some toxin exposures, there is evidence of a u-shaped curve (chronic exposure to higher levels are bad, but so are chronic exposures to very low levels, whereas intermittent exposure to lowish levels may be best). This is explained by mitohormesis. At very low levels, there is no stress so mitochondria do not get enhanced (excess recovery phase). At lowish levels, there is hormesis, so they get more enhanced with time. At high levels, they are overwhelmed by damage (excess stressor phase). It may seem counter-intuitive but there is quite a lot of evidence for this. Please note that some toxins (such as lead) may not conform to the u-shaped curve (ie they are toxic at any level), but even this is not certain. Hope that helps, Matt.

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