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Thanks Miranda for explaining why causation of PD is such a complex area. I recall hearing about a study where a mathematical risk factor model was applied to PD risk, and the outcome showed that a person needed to accumulate something like 5 to 8 ‘exposures’ to develop PD symptoms. So I think the concept of the ‘exposome’ really helps to explain the complexity and variation in PD development. Thank you for your talk.
Best wishes,
Tiana